We have been conducting researches on FPP on the theme of "Healthy Aging", aimed at achieving to reduce medical costs though preventive medicine.

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Clinical Research

Year

Name of Papers

2024

Neutrophil-lymphocyte ratio and update conclusions from a 2-year double-blind rct testing fermented papaya preparation in healthy middle-aged / elderly subjects

Whole-Body Age-Related Diseases Clinical Research
2023

Effects of dietary supplementation with fermented papaya on oxidative stress, symptoms, and microbiome in Parkinson's disease

Whole-Body Age-Related Diseases Clinical Research
2022

Effectiveness of a Fermented Functional Food on Telomere Dynamics and miRNAs in Middle-Aged/Elderly Healthy Individuals: A 2-Year Randomized, Double-Blind, Controlled Clinical Trial

Whole-Body Age-Related Diseases Clinical Research
2020

MITOCHONDRIAL AND REDOX DYSFUNCTION IN POST-MENOPAUSE AS RISK FACTOR OF NEURODEGENERATIVE DISEASE: A PILOT STUDY TESTING THE ROLE OF A VALIDATED JAPANESE FUNCTIONAL FOOD

Brain Whole-Body Age-Related Diseases Neurodegenerative Disease Clinical Research
2020

Leaky Gut and Post-Prandial, Redox and Inflammatory Markers in HRT Treated Menopausal Females: Benefits by a Pharma-Grade Fermented Papaya Preparation (FPP-ORI)

Digestive System Gastrointestinal Disorder Redox Balance Clinical Research
2018

Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults　- A Short Report of a Placebo-Controlled Clinical Trial

Circulatory System Whole-Body Age-Related Diseases Clinical Research
2018

Beneficial effects of a FPP for the treatment of electrohypersensitivity -self reporting patients : results of a phase I - II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis.

Brain Cardiac and Cerebrovascular Disorders Clinical Research
2017

A 2-year Double-Blind RCT Follow-up Study with Fermented Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered Neurodegenerative Disease-Risk Factors

Brain Age-Related Diseases Neurodegenerative Disease Clinical Research
2017

May Dietary Supplementation Augment Respiratory Burst in Wound-Site Inflammatory Cells?

Endocrine System Chronic Wound Type II Diabetes Clinical Research
2016

Effect of a quality-controlled fermented nutraceutical on skin aging markers: An antioxidant-control, double-blind study

Skin Age-Related Diseases Clinical Research

Clinical Research

Basic Research

Year

Name of Papers

2020

Beneficial Effects of Fermented Papaya Preparation (FPP)Supplementation on Redox Balance and Aging in a Mouse Model

Whole-Body Age-Related Diseases Redox Balance Basic Research
2019

Oral Administration of FPP Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response

Skin Whole-Body Age-Related Diseases Cancer Basic Research
2016

Fermented papaya preparation modulates the progression of N-methyl-N-nitrosourea induced hepatocellular carcinoma in Balb/c mice

Digestive System Cancer Chronic Liver Disease Basic Research
2015

The Effect of Fermented Papaya Preparation on Radioactive Exposure.

Blood Whole-Body Radiation Exposure Basic Research
2015

The Antioxidant Effect of Fermented Papaya Preparation in the Oral Cavity.

Oral Cavity Oral Environment Basic Research
2015

Does Oral Supplementation of a FPP Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients?

Endocrine System Type II Diabetes Basic Research Clinical Research
2014

THE HIDDEN PHENOMENON OF OXIDATIVE STRESS DURING TREATMENT OF SUBCLINICAL-MILD HYPOTHYROIDISM: A PROTECTIVE NUTRACEUTICAL INTERVENTION

Endocrine System Thyroid Disease Basic Research Clinical Research
2013

The inhibitory effect of a fermented papaya preparation on growth, hydrophobicity, and acid production of Streptococcus mutans, Streptococcus mitis, and Lactobacillus acidophilus: its implications in oral health improvement of diabetics

Oral Cavity Oral Environment Basic Research
2012

The Antioxidant effect of Fermented Papaya Preparation (FPP)　Involves Iron Chelation

Circulatory System Impairment of Iron Metabolism Basic Research
2010

Improved function of diabetic wound-site macrophages and accelerated wound closure in response to oral supplementation of a fermented papaya preparation

Endocrine System Skin Chronic Wound Type II Diabetes Basic Research

Review Paper

Year

Name of Papers

2012

Functional foods in genomic medicine: a review of fermented papaya preparation research progress

Review Paper
2010

Applications and bioefficacy of the functional food supplement fermented papaya preparation

Review Paper

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